Read Prolonged Postsynaptic Depolarisation
A short NSEB read on prolonged postsynaptic depolarisation, followed by the linked original question(s).
Prolonged Postsynaptic Depolarisation is the central idea in this question pattern. Identify the condition in the stem before applying the method below.
Core idea
A postsynaptic membrane remains depolarised when inward positive current persists or outward positive current is reduced. Opening ligand-gated Na⁺/Ca²⁺ channels can depolarise it; inhibiting K⁺ channels slows repolarisation by reducing K⁺ efflux. Match the observed duration to the direction of ion movement, not just the channel name.
Reduced potassium efflux or sustained sodium entry
The final key accepts A or B. Sustained sodium influx can maintain depolarisation, and inhibition of potassium channels can prolong it by reducing repolarising potassium efflux.
OlympIQ exam lens
- ✓A postsynaptic membrane remains depolarised when inward positive current persists or outward positive current is reduced.
Identify the biological mechanism first, then check that the option states it accurately and answers the exact question.
Ready to try the pattern?
100% coverage across the linked question.
Practise the linked question