Read the Hormones that Tune Renal Function
Hormones respond to pressure, blood volume and osmolarity to adjust filtration and the final urine.
Hormonal Regulation of Kidney Function is the central idea in this question pattern. Identify the condition in the stem before applying the method below.
RAAS restores pressure
Low renal perfusion stimulates JG cells to release renin. Renin forms angiotensin I; ACE forms angiotensin II, which raises vascular tone and stimulates aldosterone. Aldosterone acts mainly on late DCT and cortical collecting duct to increase sodium reabsorption.
Conserve or release water and salt
ADH increases water reabsorption in late DCT and collecting ducts. High atrial stretch releases ANF, which counters RAAS. The JGA includes afferent-arteriole juxtaglomerular cells and DCT macula densa; it is not confined to cortical nephrons. Alcohol and tea are the diuretics in the listed set.
OlympIQ exam lens
- ✓Renin → angiotensin I → ACE → angiotensin II → aldosterone.
- ✓ADH: water reabsorption in late DCT/collecting duct.
- ✓ANF opposes RAAS.
- ✓Aldosterone: DCT and cortical collecting duct.
ADH primarily changes water permeability; aldosterone primarily increases sodium reabsorption.
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